In this article, we speak with Mauro Mileni, Ph.D. and Chris Roth, Ph.D. about how scientists are leveraging the right technology to fill an innovative drug pipeline.
In this article, we speak with Nicole Stobart, Jeff Wilson, and Mark Schmidt, about how CAS is using authority constructs to index biological molecules.
In this article, we speak with Iddo Friedberg, an expert in protein function prediction, about how well current prediction models are performing and more.
Learn how antibody-drug conjugates (ADCs) are transforming cancer treatment with their targeted and potent action. Discover the latest trends and developments in ADC research and development.
In this Challenges and Opportunities article, we talk with Jefferson Parker, an expert in data analytics for life sciences, about sequence analysis for drug discovery and the frontiers for AI in computational biology.
In this edition of the CAS article series, Challenges & Opportunities in Drug Discovery, we talk with Ben Taft, the Senior Director of Chemistry at Via Nova Therapeutics, about structure-activity relationship studies and the possible frontiers for bioactivity data.
Learn more about ACE2 the critical protein that remains the critical target of COVID-19 and so many additional viral infections. This overviews emerging trends and insights on publications, milestones, and future applications to target ACE2 proteins.
Landscape view of emerging contributors, companies, and researchers in the emerging field of exosome research. This article overviews key players in diagnostics and therapeutic fields of exosome research with a deeper look into the current clinical pipeline.
Exosomes’ unique physical properties could unlock massive changes in the fields of drug delivery and diagnostics. However, the biggest challenge for exosomes is the methodologies of isolation and purification – this article discusses the recent trends and applications of exosomes in drug delivery, diagnostics, and therapeutics.
Learn more about lipid nanoparticles, their origin, role in COVID vaccines, and future applications. This overviews emerging trends and insights on publications, milestones, and future applications in vaccines, drug delivery, and non-therapeutic applications like agro-chemistry, cosmetics, and food science.
Learn more about cytokine storms and their role in both immunity and severe infection with COVID-19 and additional viral infections. This overviews emerging trends and insights on publications, milestones, and future applications to minimize the impact of cytokine adverse effects.
Find out how companies improve their prediction accuracy, obtain Breakthrough Technology Status and shorten the development and review time of new drugs by leveraging CAS advanced machine learning methods.
This blog details the recently published CAS indicator of drug innovation based on the structural novelty of new molecular entities (NMEs) which may better assess innovativeness of new drugs.
It is estimated that one in five human cancers involve RAS mutations. Although once considered undruggable, this blog looks at recent advances in RAS inhibitors and emerging therapies.
The COVID pandemic revealed deficiencies in mask development and production. Innovation will be crucial in slowing the spread of new variants of the virus. There are many factors that can be improved for masks, and this article focuses on the emerging science of improving filtration and microorganism removal.
As COVID-19 cases rise again worldwide, the Omicron subvariant BA.5 is currently the dominant strain. This blog explores some key mutations that increase transmission, evade protective antibodies, and increase the rate of (re)infection.
This blog lists and discusses the common ingredients (both in the household and scientific contexts) as well as the unique ingredients used in the Covid-19 vaccines currently in use in the United States, and also addresses the dosage levels proposed for children under five years of age.
Preliminary study of the Omicron variant indicates that it has evolved significantly from the original version of the virus first identified in China in 2019, which means there is an increased likelihood that it could reinfect those who have already had COVID-19 or evade the immunity generated by the current first generation of vaccines. Such a variant could drastically set back the global pandemic recovery, resulting in staggering societal and economic impacts.
Learn how machine learning procedures and CAS COVID-19 resources, including scientific insights, open access datasets and special reports are assisting in the research to fight against COVID-19.
In support of ongoing research efforts to identify additional drugs for COVID-19, a team of CAS scientists analyzed published scientific information and created a comprehensive report focusing on proteins involved in COVID-19 and potential corresponding drug candidates. Learn how CAS has committed to leveraging their assets and capabilities to support the fight against COVID-19.
A critical step in the race to develop treatments for COVID-19 is to gain a clear understanding of how the virus enters our cells. This insight will support development of targeted anitviral treatments focused on blocking that pathway.
AI re-defines natural product drug discovery. See how machine learning unlocks diverse drug candidates from plants, microbes & more, accelerating discovery
Antimicrobial-resistant infections are a global public health crisis. In a race against drug-resistant bacteria, new solutions like AI, alternative therapeutics, and innovations in materials.
Learn how mRNA vaccines, which have revolutionized the fight against COVID-19, can also be used to treat cancer by harnessing the power of the immune system.
Learn how to overcome PEG immunogenicity, a challenge that affects the safety and efficacy of PEGylated lipid nanoparticles for drug delivery. This article reviews the current state-of-the-art in addressing PEG immunogenicity, from elucidating the factors that influence anti-PEG antibody production to developing novel drug vehicles or optimizing administration and posology.
The gut microbiome is a complex ecosystem of trillions of bacteria that live in our digestive tracts with health benefits like immunity, improved mental health, and therapeutic options. In recent years, there has been a growing interest in the potential of microbiome therapies to treat a variety of diseases. As our understanding of the gut microbiome continues to grow, we can expect to see more advances in microbiome therapies in the years to come.
Stay ahead of the curve with the latest in emerging science and cutting-edge research that is accelerating the landscape of innovation. From new discoveries in synthetic biology to breakthroughs in sustainable energy, these are the breakthroughs that will reshape 2023. The experts at CAS reveal unique analysis and emerging trends from their landscape view of the world’s science.
A historical overview of the discovery of exosomes, key milestones in their rise, and why they will revolutionize the diagnostic and drug delivery fields in the future.
Learn about the basics of click chemistry and bioorthogonal chemistry that was recently awarded the 2022 Nobel Prize in Chemistry. Read about emerging trends, insights on publication trends, and future applications of bioorthogonal chemistry.
"When you’re finished changing, you’re finished." Business leaders likely weren't the intended audience when Benjamin Franklin uttered his now famous quote. However, his words likely resonate deeply with leaders in today's rapidly evolving marketplace who know that for their business to thrive, they must be prepared to adapt and embrace new technologies.
mRNA vaccines have many potential advantages over conventional vaccines in mitigating the spread and eventually ending the COVID-19 pandemic. Learn more about mRNA vaccines and how CAS is committed to supporting the fight against COVID-19.
Molecular glues have been used to uncover new therapeutic agents. Because of their targeted protein degradation that holds them together, these glues have exciting potential in uncovering new drugs to fight cancer, immune diseases, and more.
With recent headlines on monkeypox, learn more about the research landscape, scientific profiles, and currently available therapies. A deeper understanding of the published science enables clarity and insight on this emerging news story.
We are in the midst of a therapeutic revolution, according to the authors of a recent review article in Frontiers in Bioengineering and Biotechnology. They were commenting on the rapid expansion of RNA therapeutics in modern research and clinical development, driven in part by interest in RNA COVID-19 vaccines in the ongoing SARS-CoV-2 pandemic.
Gut microbiota, gut flora, or microbiome are the microorganisms that live in the digestive tracts of humans and other animals. While some bacteria are associated with disease, others are particularly important for many aspects of health and mental health.
With recent mRNA booster recommendations, many ask if they should get a COVID-19 booster and what the science shows? This blog explains the science of boosters, reviews current recommendations, and examines recent research.
